Gastrointestinal stromal tumors (GISTs) express somatostatin receptors and bind radiolabeled somatostatin analogs.
Identifieur interne : 000678 ( Main/Exploration ); précédent : 000677; suivant : 000679Gastrointestinal stromal tumors (GISTs) express somatostatin receptors and bind radiolabeled somatostatin analogs.
Auteurs : RBID : pubmed:23116418English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Female, Gastrointestinal Neoplasms (genetics), Gastrointestinal Neoplasms (metabolism), Gastrointestinal Stromal Tumors (genetics), Gastrointestinal Stromal Tumors (metabolism), Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Isotope Labeling, Lutetium (metabolism), Male, Middle Aged, Octreotide (analogs & derivatives), Octreotide (metabolism), Protein Binding, Radiopharmaceuticals (metabolism), Receptors, Somatostatin (genetics), Receptors, Somatostatin (metabolism), Retrospective Studies, Somatostatin (analogs & derivatives), Somatostatin (metabolism), Young Adult.
- MESH :
- chemical , analogs & derivatives : Octreotide, Somatostatin.
- chemical , genetics : Receptors, Somatostatin.
- chemical , metabolism : Lutetium, Octreotide, Radiopharmaceuticals, Receptors, Somatostatin, Somatostatin.
- genetics : Gastrointestinal Neoplasms, Gastrointestinal Stromal Tumors.
- metabolism : Gastrointestinal Neoplasms, Gastrointestinal Stromal Tumors.
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Isotope Labeling, Male, Middle Aged, Protein Binding, Retrospective Studies, Young Adult.
Abstract
Gastrointestinal stromal tumors (GISTs) can be effectively treated with tyrosine kinase inhibitors (TKIs). However, some patients with GIST develop drug resistance, and alternative treatment strategies are therefore needed. The aim of this study was to analyze the expression of somatostatin receptors (SSTR) in GIST as a target for peptide receptor-mediated radiotherapy (PRRT).
DOI: 10.3109/0284186X.2012.733075
PubMed: 23116418
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Gastrointestinal stromal tumors (GISTs) express somatostatin receptors and bind radiolabeled somatostatin analogs.</title><author><name sortKey="Arne, Gabriella" uniqKey="Arne G">Gabriella Arne</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Sahlgrenska Cancer Center, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Pathology, Sahlgrenska Cancer Center, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg</wicri:regionArea></affiliation></author><author><name sortKey="Nilsson, Bengt" uniqKey="Nilsson B">Bengt Nilsson</name></author><author><name sortKey="Dalmo, Johanna" uniqKey="Dalmo J">Johanna Dalmo</name></author><author><name sortKey="Kristiansson, Erik" uniqKey="Kristiansson E">Erik Kristiansson</name></author><author><name sortKey="Arvidsson, Yvonne" uniqKey="Arvidsson Y">Yvonne Arvidsson</name></author><author><name sortKey="Forssell Aronsson, Eva" uniqKey="Forssell Aronsson E">Eva Forssell-Aronsson</name></author><author><name sortKey="Nilsson, Ola" uniqKey="Nilsson O">Ola Nilsson</name></author><author><name sortKey="Ahlman, H Kan" uniqKey="Ahlman H">Håkan Ahlman</name></author></titleStmt><publicationStmt><date when="2013">2013</date><idno type="doi">10.3109/0284186X.2012.733075</idno><idno type="RBID">pubmed:23116418</idno><idno type="pmid">23116418</idno><idno type="wicri:Area/Main/Corpus">000960</idno><idno type="wicri:Area/Main/Curation">000960</idno><idno type="wicri:Area/Main/Exploration">000678</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Child</term><term>Female</term><term>Gastrointestinal Neoplasms (genetics)</term><term>Gastrointestinal Neoplasms (metabolism)</term><term>Gastrointestinal Stromal Tumors (genetics)</term><term>Gastrointestinal Stromal Tumors (metabolism)</term><term>Gene Expression Profiling</term><term>Gene Expression Regulation, Neoplastic</term><term>Humans</term><term>Isotope Labeling</term><term>Lutetium (metabolism)</term><term>Male</term><term>Middle Aged</term><term>Octreotide (analogs & derivatives)</term><term>Octreotide (metabolism)</term><term>Protein Binding</term><term>Radiopharmaceuticals (metabolism)</term><term>Receptors, Somatostatin (genetics)</term><term>Receptors, Somatostatin (metabolism)</term><term>Retrospective Studies</term><term>Somatostatin (analogs & derivatives)</term><term>Somatostatin (metabolism)</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Octreotide</term><term>Somatostatin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptors, Somatostatin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Lutetium</term><term>Octreotide</term><term>Radiopharmaceuticals</term><term>Receptors, Somatostatin</term><term>Somatostatin</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Gastrointestinal Neoplasms</term><term>Gastrointestinal Stromal Tumors</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Gastrointestinal Neoplasms</term><term>Gastrointestinal Stromal Tumors</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Child</term><term>Female</term><term>Gene Expression Profiling</term><term>Gene Expression Regulation, Neoplastic</term><term>Humans</term><term>Isotope Labeling</term><term>Male</term><term>Middle Aged</term><term>Protein Binding</term><term>Retrospective Studies</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Gastrointestinal stromal tumors (GISTs) can be effectively treated with tyrosine kinase inhibitors (TKIs). However, some patients with GIST develop drug resistance, and alternative treatment strategies are therefore needed. The aim of this study was to analyze the expression of somatostatin receptors (SSTR) in GIST as a target for peptide receptor-mediated radiotherapy (PRRT).</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">23116418</PMID><DateCreated><Year>2013</Year><Month>04</Month><Day>08</Day></DateCreated><DateCompleted><Year>2013</Year><Month>10</Month><Day>31</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1651-226X</ISSN><JournalIssue CitedMedium="Internet"><Volume>52</Volume><Issue>4</Issue><PubDate><Year>2013</Year><Month>May</Month></PubDate></JournalIssue><Title>Acta oncologica (Stockholm, Sweden)</Title><ISOAbbreviation>Acta Oncol</ISOAbbreviation></Journal><ArticleTitle>Gastrointestinal stromal tumors (GISTs) express somatostatin receptors and bind radiolabeled somatostatin analogs.</ArticleTitle><Pagination><MedlinePgn>783-92</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3109/0284186X.2012.733075</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Gastrointestinal stromal tumors (GISTs) can be effectively treated with tyrosine kinase inhibitors (TKIs). However, some patients with GIST develop drug resistance, and alternative treatment strategies are therefore needed. The aim of this study was to analyze the expression of somatostatin receptors (SSTR) in GIST as a target for peptide receptor-mediated radiotherapy (PRRT).</AbstractText><AbstractText Label="MATERIAL AND METHODS" NlmCategory="METHODS">Expression profiling of SSTR1-5 was performed on biopsies from 34 GISTs (16 gastric tumors, 15 small intestinal tumors, and three rectal tumors). SSTR scintigraphy ((111)In-octreotide) and measurement of (111)In activity in tumor specimens was performed in seven patients. Uptake and internalization of (177)Lu- octreotate was studied in primary cell cultures from two patients.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Quantitative PCR analysis showed expression of SSTR1 and SSTR2 in the majority of tumors, while SSTR3-5 were expressed at low levels. Immunohistochemical analysis confirmed the presence of SSTR1 and SSTR2 proteins in all GISTs, and SSTR3-5 in a subset of tumors. Diagnostic imaging by SSTR scintigraphy, using (111)In-octreotide, demonstrated tumor uptake of (111)In in three of six GIST patients. Measurement of (111)In activity in excised tumor specimens from five patients gave tumor-to-blood (T/B) activity ratios of between eight and 96. Tumor cells in primary culture (gastric and small intestinal GIST) specifically bound and internalized (177)Lu when incubated with the therapeutic compound (177)Lu-octreotate for 4-48 hours (p < 0.05).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Peptide receptor-mediated radiotherapy via SSTR may provide a novel treatment strategy in carefully selected GIST patients with TKI-resistant tumors.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Arne</LastName><ForeName>Gabriella</ForeName><Initials>G</Initials><Affiliation>Department of Pathology, Sahlgrenska Cancer Center, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.</Affiliation></Author><Author ValidYN="Y"><LastName>Nilsson</LastName><ForeName>Bengt</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Dalmo</LastName><ForeName>Johanna</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Kristiansson</LastName><ForeName>Erik</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Arvidsson</LastName><ForeName>Yvonne</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Forssell-Aronsson</LastName><ForeName>Eva</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Nilsson</LastName><ForeName>Ola</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Ahlman</LastName><ForeName>Håkan</ForeName><Initials>H</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>11</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Acta Oncol</MedlineTA><NlmUniqueID>8709065</NlmUniqueID><ISSNLinking>0284-186X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Radiopharmaceuticals</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Receptors, Somatostatin</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>indium-111-octreotide</NameOfSubstance></Chemical><Chemical><RegistryNumber>51110-01-1</RegistryNumber><NameOfSubstance>Somatostatin</NameOfSubstance></Chemical><Chemical><RegistryNumber>5H0DOZ21UJ</RegistryNumber><NameOfSubstance>Lutetium</NameOfSubstance></Chemical><Chemical><RegistryNumber>RWM8CCW8GP</RegistryNumber><NameOfSubstance>Octreotide</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Gastrointestinal Neoplasms</DescriptorName><QualifierName MajorTopicYN="Y">genetics</QualifierName><QualifierName MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Gastrointestinal Stromal Tumors</DescriptorName><QualifierName MajorTopicYN="Y">genetics</QualifierName><QualifierName MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Gene Expression Profiling</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Gene Expression Regulation, Neoplastic</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Isotope Labeling</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Lutetium</DescriptorName><QualifierName MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Octreotide</DescriptorName><QualifierName MajorTopicYN="N">analogs & derivatives</QualifierName><QualifierName MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Protein Binding</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Radiopharmaceuticals</DescriptorName><QualifierName MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Receptors, Somatostatin</DescriptorName><QualifierName MajorTopicYN="N">genetics</QualifierName><QualifierName MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Somatostatin</DescriptorName><QualifierName MajorTopicYN="N">analogs & derivatives</QualifierName><QualifierName MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="aheadofprint"><Year>2012</Year><Month>11</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>11</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>11</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>11</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.3109/0284186X.2012.733075</ArticleId><ArticleId IdType="pubmed">23116418</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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